Лаборатория занимается внутриклеточной доставкой биологически активных веществ (таких как генетический материал, пептидные регуляторные факторы, цитотоксические противораковые лекарства, в т. ч. радионуклиды, фотосенсибилизаторы) в заданные компартменты клеток-мишеней с использованием естественных механизмов внутриклеточного транспорта макромолекул. Разработанные в лаборатории модульные нанотранспортеры придают доставляемым лекарствам клеточную специфичность и значительно — в сотни и тысячи раз — усиливают их эффективность.
Group leader
Alexander Sobolev
Ph.D., Dr.Sc.
Professor
Corresponding Member of the Russian Academy of Sciences
Group Leader
Lab. of Molecular Genetics of Intracellular Transport
Professor
Corresponding Member of the Russian Academy of Sciences
Group Leader
Lab. of Molecular Genetics of Intracellular Transport
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E-mail:sobolev@genebiology.ru
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ORCID:0000-0001-8315-7764
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ResearcherID:P-6302-2015
Research interests:
intracellular transport, targeted subcellular delivery of drugs
and other biologically active substances, targeted delivery of genetic material
Information
Group members
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Ph.D., Dr.Sc.
Professor, Member of the Russian Academy of Sciences
Senior Scientist
Lab. of Molecular Genetics of Intracellular TransportГеоргиев Георгий Павловичgeorgiev@genebiology.ru+7 (499) 135-60-89 -
Ph.D., Dr.Sc.
Professor
Corresponding Member of the Russian Academy of Sciences
Group Leader
Lab. of Molecular Genetics of Intracellular TransportAlexander Sobolevsobolev@genebiology.ru -
Ph.D.
Research Fellow
Lab. of Molecular Genetics of Intracellular TransportTatiana Slastnikovatslast@genebiology.ru -
Ph.D.
Senior Scientist
Lab. of molecular genetics of intracellular transportYuri Khramtsovykhram2000@mail.ru -
Ph.D., Dr.Sc.
Senior Scientist
Lab. of Molecular Genetics of Intracellular TransportAndrey Rosenkranzaar@genebiology.ru -
Junior Research Fellow
Lab. of molecular genetics of intracellular transportTatiana Lupanovatatyanalupanova@yandex.ru
Selected publications
Funding
| foundation | title |
|---|---|
| RSF | The development of new types of modular nanotransporters carrying biologically active macromolecules as a tool for selective adjustment of specified functions of living cells |
| FRMT | The development of the fundamental basis (methodology) of innovative technology of targeted delivery of drugs to degenerating dopaminergic neurons in Parkinson’s disease |
Additional Information
In 2013, the head of the laboratory Alexander S. Sobolev and the member of laboratory Andrey A. Rosenkranz were awarded the Prix Galien in the category «Best research in Russia» for the development of MNT.