The laboratory is studying the domain and spatial organization of the genome of higher eukaryotes. Special attention is paid to epigenetic mechanisms operating at the level of the three-dimensional organization of the genome. We use a wide arsenal of the so-called C-methods, which allow the detection of spatial contacts between distant genomic elements. We study the mechanisms underlying formation of the 3D genome in various groups of organisms and the role of spatial contacts between distant genomic elements in the formation of regulatory modules. The resent work is focused on characterization of the 3D genome in individual cells and search of low molecular weight agents that alter the 3D organization of the genome, which could be used as “epigenetic” drugs.
Group leader
Sergey Razin
Associated Member of the Russian Academy of Sciences
Ph.D., Dr.Sci., Professor
Head of Laboratory
Ph.D., Dr.Sci., Professor
Head of Laboratory
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Tel:(499) 135 3092
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E-mail:sergey.v.razin@inbox.ru
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ORCID:0000-0003-1976-8661
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ResearcherID:M-67019-2015
Research interersts:
Chromatin, Epigenetics, 3D genomics, Domain organization of the eukaryotic genome,
Globin genes, Functional compartmentalization of the cell nucleus,
DNA repair, cellular response to stresses
Information
Group members
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Associated Member of the Russian Academy of Sciences
Ph.D., Dr.Sci., Professor
Head of LaboratorySergey Razinsergey.v.razin@inbox.ru(499) 135 3092 -
Ph.D.
Research Scientist
Lab. of Structural and Functional Organization of ChromosomesNatalia Petrovanvpetrova@mail.ru(499) 135 9787 -
Ph.D., Dr.Sc.
Senior Scientist
Lab. of structural and functional organization of chromosomesSergey Ulianovsergey.v.ulyanov@gmail.com(499) 135 9787 -
Ph.D., Dr.Sc.
Senior Scientist
Lab. of Structural and Functional oOrganization of ChromosomesElena Ioudinkovaioudinkova@inbox.ru(499) 135 9787 -
Ph.D., Dr.Sc.
Professor
Senior Scientist
Lab. of Structural and Functional oOrganization of ChromosomesOlga Iarovaiaiarovaia@inbox.ru(499) 135 9787 -
Ph.D.
Research Fellow
Lab. of Structural and Functional Organization of ChromosomesAnastasia Kovinaanastasiyaa.kovina@gmail.com(499) 135 9787 -
Тюкачева Евгения Александровнаteja98@mail.ru
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Ph.D.
Senior Scientist
Lab. of Structural and Functional Organization of ChromosomesAnastasiia SivkinaAnastasiia.sivkina@gmail.com
Selected publications
Funding
foundation | title |
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RSF | Epigenetic mechanisms controlling eukaryotic genome functioning |
RFBR |
The role of nuclear lamina in supporting 3D genome organization in Drosophila germline cells |
RFBR | Reconfiguration of regulatory chains in structural-functional domains of eukaryotic genome using genome editing |