Our research focuses on the molecular mechanisms that regulate gene expression. Gene expression is a fundamental process for the functioning of the organism. The process proceeds through a series of consecutive steps at the molecular level: chromatin template preparation, DNA transcription, mRNA maturation and the formation of ribonucleoprotein particles, their intracellular transport, and translation on ribosomes. Each of the steps is controlled by a particular set of regulatory factors, or molecular machines, which are usually multisubunit protein complexes. Intermolecular interactions and coordinated recruitment of various factors ensure the integration of individual steps into a single process.
Laboratory of Gene Expression Regulation in Development was founded in 2013 for the implementation of contract with Russian Ministry of Education and Science No. 14.B25.31.0022 from June 26, 2013 (with a grant issued to support the scientific research projects under the supervision of the world's leading scientists). The Scientific supervisor of laboratory is Prof. Paul Schedl, Princeton University.