Lab. of Gene Expression Regulation in Development

Group leader

Yulii Shidlovskii
Ph.D., Dr.Sc.
Professor of the Russian Academy of Sciences
Group Leader
Lab. of gene expression regulation in development

Research interests:

Gene, Transcription, chromatin, mRNA, gene expression

Information

Our research focuses on the molecular mechanisms that regulate gene expression. Gene expression is a fundamental process for the functioning of the organism. The process proceeds through a series of consecutive steps at the molecular level: chromatin template preparation, DNA transcription, mRNA maturation and the formation of ribonucleoprotein particles, their intracellular transport, and translation on ribosomes. Each of the steps is controlled by a particular set of regulatory factors, or molecular machines, which are usually multisubunit protein complexes. Intermolecular interactions and coordinated recruitment of various factors ensure the integration of individual steps into a single process.

History

Laboratory of Gene Expression Regulation in Development was founded in 2013 for the implementation of contract with Russian Ministry of Education and Science No. 14.B25.31.0022 from June 26, 2013 (with a grant issued to support the scientific research projects under the supervision of the world's leading scientists). The Scientific supervisor of laboratory is Prof. Paul Schedl, Princeton University.

Current projects of laboratory

  • molecular events on chromatin template upon genes activation, mechanisms of enhancer-promoter communication and insulators functioning
  • structure and functions of transcription protein complexes, chromatin-remodeling complexes in particular
  • visualization of transcription process in living cells
  • participation of transcription factors in signaling pathways and ontogenesis control
  • mRNA biogenesis and translation, functions of CPEB family proteins in neurogenesis and gametogenesis
  • cell polarity formation in ontogenesis
  • molecular-genetics analysis and population-genetics study of UCP gene family SNPs

Publications of laboratory and scientific advisor of lab (jointly with other groups of IGB RAS)

Collaboration

Laboratory conducts joint research with several Laboratories both in Russia and abroad.

  • Paul Schedl Laboratory, Princeton University
  • Thomas Gregor Laboratory, Princeton University, USA
  • John Yates Laboratory, The Scripps Research Institute, USA http://fields.scripps.edu/
  • Ennio Giordano Laboratory, Università degli Studi di Napoli "Federico II"
  • FAME Laboratory, Centre for Research and Technology Thessaly, Greece
  • Laboratory of Immunopathology, Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk, Poland
  • Laboratory of intracellular signaling, Institute of molecular biology RAS, Moscow
  • Laboratory of biochemical genetics of animals, Institute of molecular genetics, Moscow
  • Laboratory of neurogenetics, Pavlov Institute of physiology RAS, St-Petersburg
  • Research and educational center Photonics and IR Techniques, Bauman Moscow State Technical University, Moscow
  • Department of biology and general genetics, Sechenov University, Moscow

Group members

Selected publications

Funding

Foundation Title
RSF Functioning of the CPEB proteins in oogenesis, spermatogenesis and neurogenesis: mRNA localization, on-site translation and autoregulation
RFBR Studying the role of chromatin remodeler Brahma and its associated factors in gene expression regulation